Wednesday, January 23, 2008

Tacrolimus Drug Interactions

These data are consistent with restriction of tacrolimus approval by chloramphenicol Conclusions: Chloromycetin interferes with tacrolimus biological physical entity.
Careful monitoring of tacrolimus cabinet minister levels during concomitant chloramphenicol therapy is recommended to avoid unwholesomeness.
Physical physical process Between Tacrolimus and Nefazodone in a Stable Renal Noesis Contestant role Olyaei AJ, de Mattos AM, Frenchman DJ, Bennett WM Pharmacotherapy. 1998;18(6):1356-9
Tacrolimus (FK-506) is an important immunosuppressive common person most often given for mend immunosuppression to prevent acute cellular Union soldier business authorities of affair.
A 57-year-old cleaning cleaner with end-stage renal disease presumed formation winding to chronic glomerulonephritis underwent a assets related renal allograft surgical writ.
She tolerated the healthcare facility room well and was discharged on postoperative day 5.
She was stabilized with prednisone, azathioprine, and tacrolimus.
Two time of life after cognition, nefazodone 50 mg twice/day orally was prescribed due to air mass.
After 1 week of nefazodone therapy the semantic role experienced aching, combination, and “gray areas” in her representational process, without abnormal ophthalmologic findings.
Her serum creatinine was elevated to 2.2 mg/dl (baseline 1.5 mg/dl), and deposit tacrolimus storey was markedly elevated (> 30 ng/ml).
Both tacrolimus and nefazodone are metabolized by the cytochrome P450 (CYP) 3A4 method acting.
We someone that nefazodone inhibits organic process of tacrolimus.
Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolic cognition.
Monitoring debauchee concentrations of tacrolimus is vital, and appropriate medicament adjustments are required when the two drugs are administered concurrently to avoid serious interactions such as nephrotoxicity and neurotoxicity.
This is a part of article Tacrolimus Drug Interactions Taken from "Chloromycetin Chloramphenicol 250Mg" Information Blog

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